Palavras-chave
Enfermagem
Ferimentos e Lesões
Infecção da ferida
Revisão Sistemática
Como Citar
Resumo
Objetivou-se analisar a efetividade de polihexametileno-biguanida na carga microbiana e na incidência de infecção em pacientes com feridas. Revisão sistemática conforme recomendações do Joanna Briggs Institute e do checklist Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Incluíram-se estudos realizados em feridas agudas ou crônicas que utilizaram polihexametileno-biguanida entre 0,04% e 0,5%. Utilizaram-se ferramentas de análise do risco de viés e sistema Grading of Recommendations Assessment, Development and Evaluation para mensurar qualidade da evidência. Sete estudos (três coortes, três ensaios clínicos randomizados e um ensaio antes e depois) foram incluídos. O risco de viés foi baixo nos ensaios clínicos e moderado nas coortes. A qualidade da evidência foi moderada para carga microbiana e muito baixa para infecção. Polihexametileno-biguanida foi efetivo na redução da carga microbiana (p < 0,001) e na incidência de infecção (p < 0,001) em feridas agudas. Recomenda-se o uso de polihexametileno-biguanida para reduzir carga microbiana e infecções em feridas agudas. A heterogeneidade das intervenções e dos métodos de mensuração reforça a necessidade de novos estudos. O uso de polihexametileno-biguanida é uma estratégia efetiva para controle da carga microbiana em feridas agudas, o que respalda a tomada de decisão clínica.
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