Resumo
Objetivou-se mapear as evidências existentes na literatura sobre o papel da Salicornia sp. como terapia complementar no tratamento da Hipertensão Induzida por Obesidade. Trata-se de uma revisão integrativa realizada entre janeiro de 2019 a dezembro de 2021, nas bases de dados MEDLINE, LILACS e SciELO, atingindo um total de 70 publicações. Após a aplicação dos critérios de inclusão e exclusão, obteve-se um corpus de 10 artigos. Os estudos analisados foram realizados em sete países. Nove estudos revelaram efeitos positivos da suplementação de Salicornia na melhora da hipertensão em modelos animais. Dois deles incluíram efeitos diretos e sete efeitos indiretos. Um estudo revelou um efeito adverso da suplementação. Conclui-se que plantas do gênero Salicornia apresentam efeitos benéficos como substituto do sal comum no controle da hipertensão arterial em modelos animais. Destaca-se a necessidade de Ensaios Clínicos Randomizados para analisar o benefício em humanos.
Referências
Radovanovic CAT, Afonso Dos Santos L, De Barros Carvalho MD, Marcon SS. Arterial hypertension and other risk factors associated with cardiovascular diseases among adults. Rev Lat-Am Enfermagem. 2014; 22(4):547-553. https://doi.org/10.1590/0104-1169.3345.2450
Thomas H, Diamond J, Vieco A, Chaudhuri S, Shinnar E, Cromer S, Perel P, Mensah GA, Narula J, Johnson CO, Roth GA, Moran AE. Global Atlas of Cardiovascular Disease 2000-2016: The Path to Prevention and Control. Glob Heart. 2018 Sep;13(3):143-163. DOI: 10.1016/j.gheart.2018.09.511
Barroso WKS, Rodrigues CIS, Bortolotto LA, Mota-Gomes MA, Brandão AA, Feitosa ADM, et al. Brazilian Guidelines of Hypertension - 2020. Arq Bras Cardiol. 2021 Mar;116(3):516-658. DOI: 10.36660/abc.20201238
Oparil S, Acelajado MC, Bakris GL, Berlowitz DR, Cífková R, Dominiczak AF, Grassi G, Jordan J, Poulter NR, Rodgers A, Whelton PK. Hypertension. Nat Rev Dis Primers. 2018 Mar 22;4:18014. DOI: 10.1038/nrdp.2018.14
Ibekwe R. Modifiable Risk factors of Hypertension and Socio-demographic Profile in Oghara, Delta State; Prevalence and Correlates. Ann Med Health Sci Res. 2015 Jan-Feb;5(1):71-7. DOI: 10.4103/2141-9248.149793
Galvão RRS, Soares DA. Prevalência De Hipertensão Arterial E Fatores Associados Em Adultos: Uma Revisão Na Literatura Brasileira. Rev APS [Internet]. 2016 [acesso em 22 set 2022];19(1):139-149. Disponível em: https://periodicos.ufjf.br/index.php/aps/article/view/15427/8120
Azambuja MI, Foppa M, Maranhão MF, Achutti AC. Economic burden of severe cardiovascular diseases in Brazil: an estimate based on secondary data. Arq Bras Cardiol. 2008 Sep;91(3):148-55, 163-71. https://doi.org/10.1590/S0066-782X2008001500005
World Health Organization (WHO). Guideline: Sodium intake for adults and children [Internet]. Genova: WHO; 2012. [acesso em 15 nov 2021]. Disponível em: https://www.who.int/publications/i/item/9789241504836
Instituto Brasileiro de Geografia e Estatística (IBGE). Pesquisa de Orçamentos Familiares: 2008-2009. Análise Do Consumo Alimentar Pessoal No Brasil [Internet]. Brasília: IBGE; 2011. [acesso em 15 nov 2021]. Disponível em: https://biblioteca.ibge.gov.br/visualizacao/livros/liv50063.pdf
Ellison DH, Welling P. Insights into Salt Handling and Blood Pressure. N Engl J Med. 2021 Nov 18;385(21):1981-1993. DOI: 10.1056/NEJMra2030212
Dong B, Wang Z, Wang HJ, Ma J. Population attributable risk of overweight and obesity for high blood pressure in Chinese children. Blood Press. 2015;24(4):230-6. DOI: 10.3109/08037051.2015.1030904
Dong B, Wang Z, Wang HJ, Ma J. Associations between adiposity indicators and elevated blood pressure among Chinese children and adolescents. J Hum Hypertens. 2015 Apr;29(4):236-40. DOI: 10.1038/jhh.2014.95
Howe LD, Chaturvedi N, Lawlor DA, Ferreira DL, Fraser A, Davey Smith G, Tilling K, Hughes AD. Rapid increases in infant adiposity and overweight/obesity in childhood are associated with higher central and brachial blood pressure in early adulthood. J Hypertens. 2014 Sep;32(9):1789-96. DOI: 10.1097/HJH.0000000000000269
Kotchen TA. Obesity-related hypertension: epidemiology, pathophysiology, and clinical management. Am J Hypertens. 2010 Nov;23(11):1170-8. DOI: 10.1038/ajh.2010.172
Lamounier JA, Vilefort OR, Coutinho RL, Araújo, SS. Síndrome metabólica. Rev Med Minas Gerais [Internet]. 2003 [acesso em 22 set 2022];13(1):29-34. Disponível em: http://rmmg.org/artigo/detalhes/1563
Gomes-Alves E, Cardoso-Martins N, Mota-Santos R, Silva SSM, Ferreira SDRS. Adesão ao tratamento de usuários hipertensos assistidos por uma equipe de estratégia da saúde da família. Saúde Coletiva (Barueri). 2021;11(65): 5906–5915.
Panth N, Park SH, Kim HJ, Kim DH, Oak MH. Protective effect of salicornia europaea extracts on high salt intake-induced vascular dysfunction and hypertension. Int J Mol Sci. 2016;17(7). DOI: 10.3390/ijms17071176
Cho JY, Kim JY, Lee YG, Lee HJ, Shim HJ, Lee JH, Kim SJ, Ham KS, Moon JH. Four New Dicaffeoylquinic Acid Derivatives from Glasswort (Salicornia herbacea L.) and Their Antioxidative Activity. Molecules. 2016;21(8):1097. DOI: 10.3390/molecules21081097
Fita A, Rodríguez-Burruezo A, Boscaiu M, Prohens J, Vicente O. Breeding and domesticating crops adapted to drought and salinity: A new paradigm for increasing food production. Front Plant Sci. 2015; 6(11):1-14. DOI: 10.3389/fpls.2015.00978
Soares CB, Hoga LAK, Peduzzi M, Sangaleti C, Yonekura T, Silva D. Revisão integrativa: conceitos e métodos utilizados na enfermagem. Rev Esc Enferm USP. 2014; 48(2):335-345. https://doi.org/10.1590/S0080-6234201400002000020
Neves SC, Rodrigues LM, Bento PASS, Minayo MCS. Risk factors involved in adolescent obesity: an integrative review. Cien Saude Colet. 2021 Nov 15;26(suppl 3):4871-4884. DOI: 10.1590/1413-812320212611.3.30852019
Sotelo RNG, Centeno JEO, Arzola LIH, Ruíz EB. A multidisciplinary approach to the Biobank concept: integrative review. Cien Saude Colet. 2021 Sep;26(9):4321-4339. DOI: 10.1590/1413-81232021269.22332020
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hróbjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021 Mar 29;372:n71. https://doi.org/10.1136/bmj.n71
CEBM. Levels of Evidence Working Group. The Oxford 2011 Levels of Evidence [Internet]. CEBM; 2011. [acesso em 15 nov 2020]. Disponível em: https://www.cebm.net/wp-content/uploads/2014/06/CEBM-Levels-of-Evidence-2.1.pdf
Zhang S, Wei M, Cao C, Ju Y, Deng Y, Ye T, Xia Z, Chen M. Effect and mechanism of Salicornia bigelovii Torr. plant salt on blood pressure in SD rats. Food Funct [Internet]. 2015 Mar [acesso em 22 set 2022];6(3):920-6. Disponível em: https://pubs.rsc.org/en/content/articlelanding/2015/fo/c4fo00800f/unauth
Rahman MM, Kim MJ, Kim JH, Kim SH, Go HK, Kweon MH, Kim DH. Desalted Salicornia europaea powder and its active constituent, trans-ferulic acid, exert anti-obesity effects by suppressing adipogenic-related factors. Pharm Biol. 2018; 56(1):183-191. DOI: 10.1080/13880209.2018.1436073
Yun SE, Kang Y, Bae EJ, Hwang K, Jang HN, Cho HS, Chang SH, Park DJ. Iodine-induced thyrotoxic hypokalemic paralysis after ingestion of Salicornia herbace. Ren Fail. 2014 Apr;36(3):461-3. DOI: 10.3109/0886022X.2013.868296
Won KJ, Lee KP, Baek S, Cui L, Kweon MH, Jung SH, Ryu YK, Hong JM, Cho EA, Shin HS, Kim B. Desalted Salicornia europaea extract attenuated vascular neointima formation by inhibiting the MAPK pathway-mediated migration and proliferation in vascular smooth muscle cells. Biomed Pharmacother. 2017 Oct;94:430-438. DOI: 10.1016/j.biopha.2017.07.108
Lim YB, Kim HW, Hwang KE, Song DH, Kim YJ, Ham YK, Jang SJ, Lee CH, He FY, Choi YS, Kim CJ. Effects of Glasswort (Salicornia herbacea L.) Hydrates on Quality Characteristics of Reduced-salt, Reduced-fat Frankfurters. Korean J Food Sci Anim Resour. 2015; 35(6):783-792. DOI: 10.5851/kosfa.2015.35.6.783
Rhee MH, Park HJ, Cho JY. Salicornia herbacea: Botanical, chemical and pharmacological review of halophyte marsh plant. J Med Plants Res [Internet]. 2009 [acesso em 22 set 2022];3(8):548-555. Disponível em: https://academicjournals.org/journal/JMPR/article-full-text-pdf/E0B379F14702
Pichiah PT, Cha YS. Salicornia herbacea prevents weight gain and hepatic lipid accumulation in obese ICR mice fed a high-fat diet. J Sci Food Agric. 2015;95(15):3150-3159. DOI: 10.1002/jsfa.7054
Na EJ, Kim DJ, Kim JH, Kim GR. Recent trends in anti-obesity and anti-inflammatory studies in modern health care. Technol Heal Care. 2019;27(5):519-530. DOI: 10.3233/THC-191736
Kwon D, Kang J, Song Y. Effects of Salicornia herbacea L. supplementation on lipid peroxidation and antioxidative protein expression in rat skeletal muscle. African J Pharm Pharmacol. 2014;8(38):962-968. DOI: 10.5897/AJPP2014.4077
Straus SE, Richardson WS, Glasziou P, Haynes RB. Evidence-Based Medicine: How to Practice and Teach EBM. 3. ed. London: Elsevier; 2005.
Howick J, Glasziou P, Aronson JK. Evidence-based mechanistic reasoning. J R Soc Med. 2010 Nov;103(11):433-41. DOI: 10.1258/jrsm.2010.100146
Faggion CM Jr. Animal research as a basis for clinical trials. Eur J Oral Sci. 2015 Apr;123(2):61-4. DOI: 10.1111/eos.12175
Pires LF, Nascimento JL, Freitas RM, Gonçalves RP. Determinação dos níveis de malonaldeído e nitrito em indivíduos portadores de traço falciforme. Rev Ciências Médicas e Biológicas. 2013;12(1):65. https://doi.org/10.9771/cmbio.v12i1.6747
Chobanian AV, Hill M. National Heart, Lung, and Blood Institute Workshop on Sodium and Blood Pressure: a critical review of current scientific evidence. Hypertension. 2000 Apr;35(4):858-63. https://doi.org/10.1161/01.HYP.35.4.858
Zhu H, Pollock NK, Kotak I, Gutin B, Wang X, Bhagatwala J, Parikh S, Harshfield GA, Dong Y. Dietary sodium, adiposity, and inflammation in healthy adolescents. Pediatrics. 2014 Mar;133(3):e635-42. DOI: 10.1542/peds.2013-1794
Pothiwala P, Levine SN. Analytic review: thyrotoxic periodic paralysis: a review. J Intensive Care Med. 2010;25:71-7. https://doi.org/10.1177/0885066609358849
Lin SH, Huang CL. Mechanism of thyrotoxic periodic paralysis. J Am Soc Nephrol.2012;23:985-8. DOI: 10.1681/ASN.2012010046
Pinto ASS, Marques EMGB, Saraiva DMRF. Estilo de vida e adesão à terapêutica num grupo de pessoas portadoras de hipertensão arterial. Glob Acad Nurs. 2021;2(3):e149. https://doi.org/10.5935/2675-5602.20200149
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