Keywords
Cardiovascular Health
Endothelial Dysfunction
Arterial Stiffness
Nicotine
How to Cite
Abstract
This integrative review aimed to analyze the scientific evidence from the last five years on the impact of e-cigarette use on cardiovascular health. An integrative review was conducted using the PubMed/MEDLINE and LILACS databases, including studies published between 2020 and 2025. Studies that evaluated cardiovascular outcomes associated with e-cigarette use were selected. After the screening process, 14 studies comprised the final sample. A consistent association was observed between e-cigarette use and endothelial dysfunction, increased arterial stiffness, elevated heart rate and blood pressure, as well as inflammatory and oxidative markers. It is concluded that current evidence indicates that e-cigarette use is associated with potentially deleterious cardiovascular alterations, and is not a safe method of nicotine consumption for the cardiovascular system.
References
Kundu A, Bhatta L, Mascarenhas A, Dey AK, Dharmashankar K, Blaha MJ. Cardiovascular health effects of vaping e-cigarettes: a systematic review and meta-analysis. Heart. 2025 Jun 13;111(13):599-608. doi: 10.1136/heartjnl-2024-325030.
Meng X, Liu Y, Hou J, Wang Z, Li J, Wang H, et al. Acute effects of electronic cigarettes on vascular endothelial function: a systematic review and meta-analysis of randomized controlled trials. Eur J Prev Cardiol. 2023 Mar 27;30(5):425–435. doi: 10.1093/eurjpc/zwac248.
Mohammadi L, Rezaei S, Sharifi A, et al. Chronic e-cigarette use impairs endothelial function measured by flow-mediated dilation. Arterioscler Thromb Vasc Biol. 2022;42(7):925-33. doi:10.1161/ATVBAHA.121.317749.
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021 Mar 29;372:n71. doi: 10.1136/bmj.n71.
Correia RMG, Ferreira RS, Silva LN, Fernandes HMLG, Masson VA, Ribeiro MAS, Cannavan PMS. Método Canguru: humanização na unidade de terapia intensiva neonatal. Glob Acad Nurs. 2024;5(1):e423. https://dx.doi.org/10.5935/2675-5602.20200423.
Rose JJ, Choi S, Kim J, et al. Cardiopulmonary impact of electronic cigarettes and aerosol exposure: a scientific statement. Circulation. 2023;147(9):693-705. doi:10.1161/CIR.0000000000001160.
Critselis E, et al. Impact of electronic cigarette use on cardiovascular health. Angiology. 2024;75(2):101-10. doi:10.1177/00033197231161905.
Tansawet A, et al. Electronic cigarettes and cardiovascular diseases: an updated systematic review and network meta-analysis. Tob Induc Dis. 2025;23:15. doi:10.18332/tid/144317.
Simovic T, et al. Exploring the impact of e-cigarettes on cardiovascular health. Curr Cardiol Rev. 2025;21(1):e12012510046. doi:10.1007/s12012-025-10046-y.
American Heart Association. Cardiovascular effects of electronic cigarettes. Circulation. 2023;148(5):e1-e21. doi:10.1161/CIR.0000000000001160.
Benowitz NL, et al. Nicotine effects on the cardiovascular system with emphasis on e-cigarettes. Prog Cardiovasc Dis. 2022;70:54-61. doi:10.1016/j.pcad.2022.02.004.
Espinoza-Derout J, et al. E-cigarette exposure causes oxidative stress and endothelial dysfunction. PLoS One. 2021;16(3):e0246447. doi:10.1371/journal.pone.0246447.
Alzahrani T, et al. Association between electronic cigarette use and myocardial infarction. Am J Prev Med. 2021;60(1):123-10. doi:10.1016/j.amepre.2020.12.007.
Qasim H, Karim ZA, Silva-Espinoza JC, Rivera JO, Khasawneh FT, Almeida IC, et al. Short-Term E-Cigarette Exposure Increases the Risk of Thrombogenesis and Enhances Platelet Function in Mice. J Am Heart Assoc. 2018 Jul 18;7(15):e009264. doi: 10.1161/JAHA.118.009264.
Shahab L, et al. Cardiovascular safety of electronic cigarettes: systematic review. BMJ Open. 2022;12(1):e054989. doi:10.1136/bmjopen-2021-054989.
Chatterjee S, et al. Cardiovascular disease risk in e-cigarette users. Int J Cardiol. 2024;385:45-52. doi:10.1016/j.ijcard.2024.02.011.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2025 Global Academic Nursing Journal